Product Information
    
 
    

    

        

            

                

                
Product Name
                
                

                
Cat#
                
                

                
Size
                
                

                
Price（¥）
                
            
            

                

                
Recombinant Rat Tumor Necrosis Factor-alpha/TNFSF2
                
(Rat TNF-α/TNFSF2)
                
                

                
90628ES08
                
                

                
5 μg
                
                

                
815.00
                
            
            

                

                
90628ES60
                
                

                
100 μg
                
                

                
7865.00
                
            
            

                

                
90628ES76
                
                

                
500 μg
                
                

                
20425.00
                
            
        
    
    
    
 
    
Product Description
    
 
    
Tumor necrosis factor alpha (TNF-α), also known as cachectin, is a cachectin, is a polypeptide cytokine produced by monocytes and macrophages. TNFα receptor signaling can simultaneously activate caspase 8, the transcription factor, NF-κB and the kinase, JNK. Human TNF-α shares 97% aa sequence identity with rhesus and 71%-92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. TNF-α occurs as a secreted, soluble form and as a membrane-anchored form, both of which are biologically active. Inflammation is associated with insulin resistance, and TNF-α and IL-6 may affect glucose uptake. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. 
    
 
    
Product Properties
    
 
    

    

        

            

                

                
Synonyms
                
                

                
Tumor Necrosis Factor, TNFA, TNFSF2, Cachectin, Cytotoxin, Differentiation-inducing factor, DIF
                
            
            

                

                
Accession
                
                

                
P16599
                
            
            

                

                
GeneID
                
                

                
24835
                
            
            

                

                
Source
                
                

                
E.coli-derived rat TNF-α/TNFSF2 protein, Leu80-Leu235.
                
            
            

                

                
Molecular Weight
                
                

                
Approximately 17.2 kDa.
                
            
            

                

                
AA Sequence
                
                

                
LRSSSQNSSD KPVAHVVANH QAEEQLEWLS QRANALLANG MDLKDNQLVV PADGLYLIYS QVLFKGQGCP DYVLLTHTVS RFAISYQEKV SLLSAIKSPC PKDTPEGAEL KPWYEPMYLG GVFQLEKGDL LSAEVNLPKY LDITESGQVY FGVIAL
                
            
            

                

                
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