MEN1 Pre-design Chimera RNAi
产品名称： MEN1 Pre-design Chimera RNAi
英文名称： MEN1 Pre-design Chimera RNAi
产品编号： H00004221-R01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Homo sapiens multiple endocrine neoplasia I (MEN1), transcript variant 1, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000244
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 4221
- Gene Name:
- MEN1
- Gene Alias:
- MEAI,SCG2
- Gene Description:
- multiple endocrine neoplasia I
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq
- Other Designations:
- OTTHUMP00000042868,OTTHUMP00000070176,OTTHUMP00000070180,OTTHUMP00000070184,endocrine adenomatosis, multiple,menin
- Related Disease
- Adenocarcinoma
- Adenoma
- Adrenal Gland Neoplasms
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Hyperinsulinism
- Hyperparathyroidism
- Hyperparathyroidism, Primary
- Hypoglycemia
- Insulinoma
- Multiple endocrine neoplasia
- Multiple Endocrine Neoplasia Type 1
- Neuroendocrine Tumors
- Pancreatic cancer
- Pancreatic Neoplasms