Forskolin-其它资料-资讯-生物在线

Forskolin

作者:上海康成生物工程有限公司 2008-01-30T00:00 (访问量:3332)

Forskolin

 

Catalog No: KC-4F001

Size: 10 mg

 

Physical Appearance:  White solid, mp=229-232°C

 

Molecular Formula:  C22H34O7

 

Molecular Weight:  410.5

 

Purity:  99% (TLC)

 

Solubility:  Soluble in DMSO (5mg/ml)

 

Storage:  Store, as supplied, at –20°C for up to 1 year. Store solutions at -20°C for up to 2 months.

 

Description:  Forskolin, a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of adenylate cyclase, activating the enzyme and raising intracellular levels of cAMP. It is cell permeable and active in vivo producing positive inotropic, platelet anti-aggregatory and anti-hypertensive effects.

 

References:

1.      Merck 11, 2473

2.      Review KB Seamon Annu Rep Med Chem 1984 19 293

3.      K.B. Seamon and J.W. Daly Adv. Cyclic Nucl. Res. 1986 20 1

4.      A. Laurenza et al. Trends Pharmacol. Sci. 1989 10 442

5.      N.J. De Souza et al. Med. Res. Rev. 1983 3 201

 

The pharmacological and toxicological properties of this product have not been fully investigated.  Exercise caution in use and handling.  This product must not be used in humans.

 

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